Urinary Modified C-Reactive Protein is Closely Associated with Tubulointerstitial Lesions in Lupus Nephritis

Objective. Modified C-reactive protein (mCRP) is known to be involved in the upregulation and amplification of local inflammatory response. This study investigated circulating levels mCRP their relevance clinicopathological features patients with lupus nephritis. Methods. Ninety-five renal biopsy-proven nephritis 30 normal controls were enrolled this study. Plasma urinary screened by enzyme-linked immunosorbent assay (ELISA). The deposition was detected immunohistochemistry immunofluorescence staining. A human proximal tubular epithelial cell line (HK2 cells) incubated purified IgG from nephritis, production CRP HK2 cells further evaluated. Results. increased significantly compared ( P = 0.013 , id="M2"> < 0.001 respectively). associated interstitial infiltration (r = 0.514, id="M3"> ) fibrosis 0.270, id="M4"> 0.008 ). ROC–AUC for diagnosing tubulointerstitial lesions 0.766. closely poor outcomes (HR: 1.204, 95% CI: 1.029–1.409, id="M5"> 0.020 However, no correlations found plasma data or prognosis mostly deposited tubules expression correlated lesion indices. Immunofluorescence staining showed that could colocalize tubules. Lupus nephritis-derived induce cells. Conclusion. Urinary increased, might a biomarker Renal produced after stimulation IgG, presence play critical role development lesions.